Research workbench
Mechanism of substrate release in NEUROTRANSMITTER:SODIUM symporters: the structure of leut in an inward-facing occluded conformation
Analyse Mechanism of substrate release in NEUROTRANSMITTER:SODIUM symporters: the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XWM
- Type
- protein
- Length
- 993 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NA(+):NEUROTRANSMITTER symporter (snf family)
- UniProt
- O67854
- Ligands
- PHE, NA
- Pockets
- 15 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NA(+):NEUROTRANSMITTER symporter (snf family) | protein | 498 | 77% helix, 1% strand | O67854 |
| B | NA(+):NEUROTRANSMITTER symporter (snf family) | protein | 495 | 78% helix, 1% strand | O67854 |
Ligands and binding sites
- PHE · Phenylalanine · ligand · 2 copies · chains A, B
- NA · Sodium ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 337 | 0.83 | 0.91 | 28 | empty |
| 2 | 473 | 0.72 | 0.82 | 50 | empty |
| 3 | 473 | 0.67 | 0.78 | 44 | empty |
| 4 | 392 | 0.65 | 0.78 | 37 | empty |
| 5 | 427 | 0.64 | 0.78 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 1269 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6XWM · Mechanism of substrate release in neurotransmitter:sodium symporters: the structure of… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67854
- Elsewhere: RCSB PDB 6XWM · PDBe 6XWM · UniProt O67854
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.