Research workbench
Crystal structure of the bright genetically encoded calcium indicator NCAMP7 based on mneongreen fluorescent protein
Analyse Crystal structure of the bright genetically encoded calcium indicator NCAMP7… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XW2
- Type
- protein
- Length
- 387 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Genetically encoded calcium indicator NCAMP7 based on mneongreen fluorescent protein
- Ligands
- CR2, CA, SO4
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Genetically encoded calcium indicator NCAMP7 based on mneongreen fluorescent protein | protein | 387 | 34% helix, 35% strand | — |
Ligands and binding sites
- CR2 · {(4Z)-2-(aminomethyl)-4-[(4-hydroxyphenyl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A
- CA · Calcium ion · metal · 4 copies · chains A
- SO4 · Sulfate ion · ion · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.72 | 0.98 | 23 | CR2, SO4 |
| 2 | 163 | 0.52 | 0.79 | 29 | empty |
| 3 | 148 | 0.45 | 0.77 | 26 | SO4 |
Modifications
Observed in the structure: 2 cofactor (chromophore).
Compared structures
- 6XW2 · Crystal structure of the bright genetically encoded calcium indicator NCaMP7 based on… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6XW2 · PDBe 6XW2
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