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Cryo-EM structure of the sodium leak channel nalcn-FAM155A complex

Analyse Cryo-EM structure of the sodium leak channel nalcn-FAM155A complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6XIW
Type
protein
Length
1,400 residues
Chains
2
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
Q8IZF0, B1AL88
Ligands
PEV, Y01, PGV, NAG

Structure

electron microscopy · 2 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein1256—Q8IZF0
B—protein144—B1AL88

Ligands and binding sites

  • PEV · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · ligand · 5 copies · chains A, B
  • Y01 · Cholesterol hemisuccinate · ligand · 3 copies · chains A
  • PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate · ligand · 2 copies · chains A
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6XIW · Cryo-EM structure of the sodium leak channel NALCN-FAM155A complex · the same entry in another collection · chain A against A, TM-score 1.00
  • Q8IZF0 · AlphaFold monomer V2.0 prediction for sodium leak channel non- selective protein (Q8IZF0) · a predicted model of the same protein · chain A against A, TM-score 0.99
  • B1AL88 · AlphaFold monomer V2.0 prediction for transmembrane protein FAM155A (B1AL88) · a predicted model of the same protein · chain B against A, TM-score 0.87

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