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Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin

Analyse Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6WZ5
Type
protein + DNA
Length
1,080 residues
Chains
10
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
P84233, P62799, Q6AZJ8, P02281

Structure

electron microscopy · 6 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A, E—protein98—P84233
B, F—protein81—P62799
C, G—protein110—Q6AZJ8
D, H—protein98—P02281
I—dna153——
J—dna153——

Compared structures

  • 6WZ5 · Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin · the same entry in another collection · chain J against J, TM-score 1.00
  • P84233 · AlphaFold monomer V2.0 prediction for histone H3.2 (P84233) · a predicted model of the same protein · chain E against A, TM-score 0.99

Analyse

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