Research workbench

Human calcium and integrin binding protein 3

Analyse Human calcium and integrin binding protein 3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6WU5
Type: protein
Length: 364 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium and integrin-binding family member 3
UniProt: Q96Q77
Ligands: CA, CL, SCN
Pockets: 5 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calcium and integrin-binding family member 3	protein	181	52% helix, 3% strand	Q96Q77
B	Calcium and integrin-binding family member 3	protein	183	51% helix, 2% strand	Q96Q77

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A, B
CL · Chloride ion · ion · 7 copies · chains A, B
SCN · Thiocyanate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	358	0.58	0.76	48	empty
2	126	0.50	0.79	18	empty
3	110	0.47	0.79	18	SCN, CL
4	80	0.34	0.75	14	empty
5	52	0.30	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 2136 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

6WU5 · Human Calcium and Integrin Binding Protein 3 · the same entry in another collection · chain A against A, TM-score 1.00
Q96Q77 · AlphaFold monomer V2.0 prediction for calcium and integrin-binding family member 3… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96Q77
Elsewhere: RCSB PDB 6WU5 · PDBe 6WU5 · UniProt Q96Q77

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