Research workbench
Plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin
Analyse Plasminogen activator inhibitor-1 complex with somatomedin B domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OC0
- Type
- protein
- Length
- 401 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plasminogen activator inhibitor-1; Vitronectin
- UniProt
- P05121, P04004
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Plasminogen activator inhibitor-1 | protein | 364 | 28% helix, 31% strand | P05121 |
| B | Vitronectin | protein | 37 | 22% helix, 5% strand | P04004 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 156 | 0.60 | 0.83 | 26 | empty |
| 2 | 79 | 0.45 | 0.81 | 17 | empty |
| 3 | 66 | 0.35 | 0.77 | 21 | empty |
| 4 | 73 | 0.33 | 0.75 | 17 | empty |
| 5 | 59 | 0.28 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 694 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1OC0 · plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin · the same entry in another collection · chain A against A, TM-score 1.00
- P05121 · AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 1 (P05121) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P04004 · AlphaFold monomer V2.0 prediction for vitronectin (P04004) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05121
- Every structure of UniProt P04004
- Elsewhere: RCSB PDB 1OC0 · PDBe 1OC0 · UniProt P05121 · UniProt P04004
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.