Research workbench
Crystal structure of human SMC1-SMC3 hinge domain heterodimer in north-open conformation
Analyse Crystal structure of human SMC1-SMC3 hinge domain heterodimer in north-open… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WG6
- Type
- protein + DNA
- Length
- 2,491 residues
- Chains
- 14
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes protein; Structural maintenance of chromosomes…
- UniProt
- G8JLG1, Q9UQE7
- Pockets
- 20 · best druggability 0.72
Structure
x-ray diffraction · 10 distinct chains · 55% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Structural maintenance of chromosomes protein | protein | 182 | 48% helix, 15% strand | G8JLG1 |
| B, H | Structural maintenance of chromosomes protein 3 | protein | 236 | 59% helix, 12% strand | Q9UQE7 |
| D | Structural maintenance of chromosomes protein 3 | protein | 235 | 59% helix, 12% strand | Q9UQE7 |
| E, G | Structural maintenance of chromosomes protein | protein | 178 | 48% helix, 15% strand | G8JLG1 |
| F | Structural maintenance of chromosomes protein 3 | protein | 235 | 60% helix, 14% strand | Q9UQE7 |
| I | Structural maintenance of chromosomes protein | protein | 173 | 47% helix, 12% strand | G8JLG1 |
| J | Structural maintenance of chromosomes protein 3 | protein | 238 | 60% helix, 11% strand | Q9UQE7 |
| K | Structural maintenance of chromosomes protein | protein | 175 | 47% helix, 14% strand | G8JLG1 |
| L | Structural maintenance of chromosomes protein 3 | protein | 239 | 60% helix, 12% strand | Q9UQE7 |
| M, N | POLY(DT) | dna | 2 | — | — |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1169 | 0.72 | 0.76 | 107 | empty |
| 2 | 987 | 0.69 | 0.74 | 85 | empty |
| 3 | 982 | 0.69 | 0.74 | 88 | empty |
| 4 | 483 | 0.64 | 0.77 | 60 | empty |
| 5 | 473 | 0.62 | 0.76 | 46 | empty |
Interfaces
28 interfaces between chains.
- B–L · 1011 Ų buried · 8 hydrogen bonds · protein-protein
- G–H · 968 Ų buried · 14 hydrogen bonds · protein-protein
- D–J · 956 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 920 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 909 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 6WG6 · Crystal structure of human SMC1-SMC3 hinge domain heterodimer in north-open conformation · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G8JLG1
- Every structure of UniProt Q9UQE7
- Elsewhere: RCSB PDB 6WG6 · PDBe 6WG6 · UniProt G8JLG1 · UniProt Q9UQE7
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