UniProt Q9UQE7
Structural maintenance of chromosomes protein 3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (UniProt Q9UQE7): 15 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 93 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9UQE7
- Protein
- Structural maintenance of chromosomes protein 3
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 93 · 12 records with a druggable one
Structures
16 records of Q9UQE7 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6WG3 | Cryo-EM structure of human Cohesin-NIPBL-DNA complex | electron microscopy | B | ANP | 10 (best 0.86) |
| 6WG3 | Cryo-EM structure of human cohesin-nipbl-DNA complex | electron microscopy | B | ANP | — |
| 6WG4 | Crystal structure of human SMC1-SMC3 hinge domain heterodimer in south-open conformation | x-ray diffraction | B | — | 1 (best 0.50) |
| 6WG4 | Crystal structure of human SMC1-SMC3 hinge domain heterodimer in south-open conformation | x-ray diffraction | B | — | — |
| 6WG6 | Crystal structure of human SMC1-SMC3 hinge domain heterodimer in north-open conformation | x-ray diffraction | B, D, F, H, J, L | — | 20 (best 0.72) |
| 6WG6 | Crystal structure of human SMC1-SMC3 hinge domain heterodimer in north-open conformation | x-ray diffraction | B, D, F, H, J, L | — | — |
| 6WGE | Cryo-EM structure of human Cohesin-NIPBL-DNA complex without STAG1 | electron microscopy | B | ANP, MG | 11 (best 0.85) |
| 6WGE | Cryo-EM structure of human cohesin-nipbl-DNA complex without STAG1 | electron microscopy | B | ANP, MG | — |
| 7W1M | Cryo-EM structure of human cohesin-CTCF-DNA complex | electron microscopy | B | ADP, BEF | 7 (best 0.90) |
| 8P0A | Human Cohesin ATPase module | electron microscopy | B | ATP, MG | 6 (best 0.80) |
| 8ROH | Human cohesin SMC3-HD(EQ)/RAD21-N complex - Apo conformation | x-ray diffraction | A | SO4 | 5 (best 0.63) |
| 8ROI | Human cohesin SMC3-HD(EQ)/RAD21-N complex - ADP-bound conformation | x-ray diffraction | A | ADP | 4 (best 0.64) |
| 8ROJ | Human cohesin SMC3-HD/RAD21-N complex - ADP-Mg-bound conformation | x-ray diffraction | A | MG, ADP | 4 (best 0.69) |
| 8ROK | Human cohesin SMC3-HD(EQ)/RAD21-N complex - ATP-Mg-bound conformation - Form 1 | x-ray diffraction | A, C | AGS, MG | 10 (best 0.85) |
| 8ROL | Human cohesin SMC3-HD(EQ)/RAD21-N complex - ATP-Mg-bound conformation - Form 2 | x-ray diffraction | A | MG, AGS | 5 (best 0.57) |
| Q9UQE7 | AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 3 (Q9UQE7) | predicted | A | — | 10 (best 0.58) |
Ligands
- MG · Magnesium ion · in 6 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 4 records
- ADP · Adenosine-5'-diphosphate · in 3 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 2 records
- ATP · Adenosine-5'-triphosphate · in 1 record
- BEF · Beryllium trifluoride ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 6WG4 chain B against the predicted model Q9UQE7: TM-score 0.97, RMSD 0.96 Å
- 6WG4 chain B against the predicted model Q9UQE7: TM-score 0.97, RMSD 0.96 Å
- 8P0A chain B against the predicted model Q9UQE7: TM-score 0.94, RMSD 1.81 Å
- 6WG6 chain D against the predicted model Q9UQE7: TM-score 0.87, RMSD 2.56 Å
- 6WG6 chain D against the predicted model Q9UQE7: TM-score 0.87, RMSD 2.56 Å
- 6WG6 chain B against the predicted model Q9UQE7: TM-score 0.86, RMSD 2.77 Å
- 6WG6 chain B against the predicted model Q9UQE7: TM-score 0.86, RMSD 2.77 Å
- 6WG6 chain F against the predicted model Q9UQE7: TM-score 0.86, RMSD 2.78 Å
- 6WG6 chain F against the predicted model Q9UQE7: TM-score 0.86, RMSD 2.78 Å
- 6WG6 chain J against the predicted model Q9UQE7: TM-score 0.86, RMSD 3.00 Å
Elsewhere
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