Research workbench
Crystal structure of human SMC1-SMC3 hinge domain heterodimer in south-open conformation
Analyse Crystal structure of human SMC1-SMC3 hinge domain heterodimer in south-open… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WG4
- Type
- protein
- Length
- 341 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes protein; Structural maintenance of chromosomes…
- UniProt
- G8JLG1, Q9UQE7
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes protein | protein | 176 | 48% helix, 16% strand | G8JLG1 |
| B | Structural maintenance of chromosomes protein 3 | protein | 165 | 52% helix, 16% strand | Q9UQE7 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.50 | 0.75 | 33 | empty |
| 2 | 63 | 0.27 | 0.73 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 799 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6WG4 · Crystal structure of human SMC1-SMC3 hinge domain heterodimer in south-open conformation · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UQE7 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 3… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G8JLG1
- Every structure of UniProt Q9UQE7
- Elsewhere: RCSB PDB 6WG4 · PDBe 6WG4 · UniProt G8JLG1 · UniProt Q9UQE7
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