K2P2.1 (trek-1), 50 mm K+

Structure

x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).

Ligands and binding sites

• D12 · Dodecane · ligand · 2 copies · chains A, B
• R16 · Hexadecane · ligand · 2 copies · chains B
• D10 · Decane · ligand · chains A
• B7G · heptyl beta-D-glucopyranoside · ligand · chains A
• LNK · Pentane · ligand · chains B
• K · Potassium ion · metal · 2 copies · chains A, B
• CD · Cadmium ion · metal · chains A
• OCT · N-octane · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 5175 Ų buried · 48 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 6W82 · K2P2.1 (TREK-1), 50 mM K+ · the same entry in another collection · chain B against B, TM-score 1.00
• P97438 · AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 2 (P97438) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P97438
• Elsewhere: RCSB PDB 6W82 · PDBe 6W82 · UniProt P97438