UniProt P97438
Potassium channel subfamily K member 2 (P97438)
Potassium channel subfamily K member 2 (UniProt P97438): 38 experimental structures on GenesisL1, 15 ligands bound, 284 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P97438
- Protein
- Potassium channel subfamily K member 2
- Experimental structures
- 38
- Predicted models
- 0
- Ligands
- 15
- Pockets
- 284 · 20 records with a druggable one
Structures
38 records of P97438 in the MolNFT archive: 38 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CQ6 | K2P2.1(TREK-1) apo structure | x-ray diffraction | A, B | CD, K, D10 | 14 (best 0.74) |
| 6CQ6 | K2P2.1(TREK-1) apo structure | x-ray diffraction | A, B | CD, K, D10 | — |
| 6CQ8 | K2P2.1(TREK-1):ML335 complex | x-ray diffraction | A, B | K, R16, Q6F, 16C, CD | 14 (best 0.81) |
| 6CQ8 | K2P2.1(TREK-1):ML335 complex | x-ray diffraction | A, B | K, R16, Q6F, 16C, CD | — |
| 6CQ9 | K2P2.1(TREK-1):ML402 complex | x-ray diffraction | A, B | K, Q5F, R16, 16C, CD | 16 (best 0.78) |
| 6CQ9 | K2P2.1(TREK-1):ML402 complex | x-ray diffraction | A, B | K, Q5F, R16, 16C, CD | — |
| 6W7B | K2P2.1 (TREK-1), 0 mM K+ | x-ray diffraction | A, B | CD, D12, B7G, K, D10 | 11 (best 0.83) |
| 6W7B | K2P2.1 (trek-1), 0 mm K+ | x-ray diffraction | A, B | CD, D12, B7G, K, D10 | — |
| 6W7C | K2P2.1 (TREK-1), 1 mM K+ | x-ray diffraction | A, B | CD, D12, R16, B7G, K, D10 | 16 (best 0.81) |
| 6W7C | K2P2.1 (trek-1), 1 mm K+ | x-ray diffraction | A, B | CD, D12, R16, B7G, K, D10 | — |
| 6W7D | K2P2.1 (TREK-1), 10 mM K+ | x-ray diffraction | A, B | D12, K, LNK, CD, R16 | 14 (best 0.67) |
| 6W7D | K2P2.1 (trek-1), 10 mm K+ | x-ray diffraction | A, B | D12, K, LNK, CD, R16 | — |
| 6W7E | K2P2.1 (TREK-1), 30 mM K+ | x-ray diffraction | A, B | CD, LNK, K, PIO, D12, R16 | 13 (best 0.71) |
| 6W7E | K2P2.1 (trek-1), 30 mm K+ | x-ray diffraction | A, B | CD, LNK, K, PIO, D12, R16 | — |
| 6W82 | K2P2.1 (TREK-1), 50 mM K+ | x-ray diffraction | A, B | CD, D12, D10, B7G, K, LNK | 14 (best 0.79) |
| 6W82 | K2P2.1 (trek-1), 50 mm K+ | x-ray diffraction | A, B | CD, D12, D10, B7G, K, R16 | — |
| 6W83 | K2P2.1 (TREK-1), 100 mM K+ | x-ray diffraction | A, B | CD, D12, K, R16, D10 | 14 (best 0.77) |
| 6W83 | K2P2.1 (trek-1), 100 mm K+ | x-ray diffraction | A, B | CD, D12, K, R16, D10 | — |
| 6W84 | K2P2.1 (TREK-1), 200 mM K+ | x-ray diffraction | A, B | CD, D12, K | 10 (best 0.76) |
| 6W84 | K2P2.1 (trek-1), 200 mm K+ | x-ray diffraction | A, B | CD, D12, K | — |
| 6W85 | K2P2.1 (TREK-1):ML335 complex, 200 mM K+ | x-ray diffraction | A, B | K, Q6F, CD, D10, R16 | 16 (best 0.78) |
| 6W85 | K2P2.1 (trek-1):ML335 complex, 200 mm K+ | x-ray diffraction | A, B | K, Q6F, CD, D10, R16 | — |
| 6W86 | K2P2.1 (TREK-1):ML335 complex, 100 mM K+ | x-ray diffraction | A, B | K, Q6F, LNK, D12, CD, R16 | 14 (best 0.80) |
| 6W86 | K2P2.1 (trek-1):ML335 complex, 100 mm K+ | x-ray diffraction | A, B | K, Q6F, LNK, D12, CD, R16 | — |
| 6W87 | K2P2.1 (TREK-1):ML335 complex, 50 mM K+ | x-ray diffraction | A, B | K, Q6F, D12, D10, CD, R16 | 14 (best 0.76) |
| 6W87 | K2P2.1 (trek-1):ML335 complex, 50 mm K+ | x-ray diffraction | A, B | K, Q6F, D12, D10, CD, R16 | — |
| 6W88 | K2P2.1 (TREK-1):ML335 complex, 30 mM K+ | x-ray diffraction | A, B | Q6F, CD, D12, D10, LNK, R16 | 14 (best 0.80) |
| 6W88 | K2P2.1 (trek-1):ML335 complex, 30 mm K+ | x-ray diffraction | A, B | Q6F, CD, D12, D10, LNK, R16 | — |
| 6W8A | K2P2.1 (TREK-1):ML335 complex, 10 mM K+ | x-ray diffraction | A, B | K, Q6F, 16C, R16, CD, LNK | 15 (best 0.80) |
| 6W8A | K2P2.1 (trek-1):ML335 complex, 10 mm K+ | x-ray diffraction | A, B | K, Q6F, 16C, R16, CD, LNK | — |
| 6W8C | K2P2.1 (TREK-1):ML335 complex, 1 mM K+ | x-ray diffraction | A, B | K, R16, Q6F, B7G, IEP, 11A | 15 (best 0.76) |
| 6W8C | K2P2.1 (trek-1):ML335 complex, 1 mm K+ | x-ray diffraction | A, B | K, R16, Q6F, B7G, IEP, 11A | — |
| 6W8F | K2P2.1 (TREK-1):ML335 complex, 0 mM K+ | x-ray diffraction | A, B | K, Q6F, 16C, R16, CD, LNK | 13 (best 0.81) |
| 6W8F | K2P2.1 (trek-1):ML335 complex, 0 mm K+ | x-ray diffraction | A, B | K, Q6F, 16C, R16, CD, LNK | — |
| 8UE2 | Structure of TREK-1CG*:ML335 | x-ray diffraction | A, B | K, R16, D10, Q6F, CD | 14 (best 0.78) |
| 8UEC | Structure of TREK-1CG*:CAT335a | x-ray diffraction | A, B | 16C, D10, WUZ, K, R16, CD | 15 (best 0.81) |
| 8UF6 | Structure of Trek-1(K2P2.1) with ML336 | x-ray diffraction | A, B | WRZ, D10, K, 16C, CD, D12 | 18 (best 0.75) |
| P97438 | AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 2 (P97438) | — | — | — |
Ligands
- CD · Cadmium ion · in 37 records
- K · Potassium ion · in 37 records
- R16 · Hexadecane · in 31 records
- D12 · Dodecane · in 26 records
- D10 · Decane · in 21 records
- LNK · Pentane · in 17 records
- Q6F · N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl) amino]benzamide · in 17 records
- 16C · N-((E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl)palmitamide · in 10 records
- B7G · heptyl beta-D-glucopyranoside · in 8 records
- 11A · Undecanoic acid · in 2 records
- IEP · [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R}, 3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate · in 2 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 2 records
- Q5F · N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide · in 2 records
- WRZ · N-[(2,4-dichlorophenyl)methyl]-4-propanamidobenzamide · in 1 record
- WUZ · N-[(2,4-dichlorophenyl)methyl]-4-[(3R)-3-methyl-2,5-dioxopyrrolidin-1-yl]benzamide · in 1 record
Elsewhere
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