MolNFT v1 · #168160 · protein

K2P2.1 (trek-1), 0 mm K+

6W7B · Potassium channel subfamily K member 2: “K2P2.1 (trek-1), 0 mm K+”. X-ray diffraction, 5 ligands (D12, B7G, D10), 11 pockets (best druggability 0.83). MolNFT v1 #168160 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6W7B
Type: protein
Length: 529 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium channel subfamily K member 2
UniProt: P97438
Ligands: D12, B7G, D10, CD, K
Pockets: 11 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Potassium channel subfamily K member 2	protein	259	77% helix, 0% strand	P97438
B	Potassium channel subfamily K member 2	protein	270	73% helix, 0% strand	P97438

Ligands and binding sites

D12 · Dodecane · ligand · 3 copies · chains A, B
B7G · heptyl beta-D-glucopyranoside · ligand · chains A
D10 · Decane · ligand · chains B
CD · Cadmium ion · metal · 2 copies · chains A, B
K · Potassium ion · metal · 2 copies · chains A, B
OCT · N-octane · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	950	0.83	0.84	94	empty
2	175	0.72	0.89	32	empty
3	567	0.67	0.77	38	empty
4	327	0.62	0.78	44	empty
5	129	0.53	0.81	21	empty

Interfaces

1 interface between chains.

A–B · 5213 Å² buried · 48 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6W7B · K2P2.1 (TREK-1), 0 mM K+ · the same entry in another collection · chain A against A, TM-score 1.00
P97438 · AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 2 (P97438) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P97438
Elsewhere: RCSB PDB 6W7B · PDBe 6W7B · UniProt P97438

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