Research workbench

K2P2.1 (trek-1), 1 mm K+

Analyse K2P2.1 (trek-1), 1 mm K+ in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6W7C
Type: protein
Length: 534 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium channel subfamily K member 2
UniProt: P97438
Ligands: D12, B7G, R16, D10, CD, K
Pockets: 16 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Potassium channel subfamily K member 2	protein	263	76% helix, 0% strand	P97438
B	Potassium channel subfamily K member 2	protein	271	75% helix, 0% strand	P97438

Ligands and binding sites

D12 · Dodecane · ligand · 3 copies · chains A, B
B7G · heptyl beta-D-glucopyranoside · ligand · 2 copies · chains A
R16 · Hexadecane · ligand · chains A
D10 · Decane · ligand · chains B
CD · Cadmium ion · metal · 3 copies · chains A, B
K · Potassium ion · metal · 3 copies · chains A, B
OCT · N-octane · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	988	0.81	0.82	104	CD
2	58	0.72	0.97	18	empty
3	568	0.67	0.77	39	K
4	219	0.61	0.80	24	empty
5	272	0.56	0.76	37	empty

Interfaces

1 interface between chains.

A–B · 5066 Å² buried · 43 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6W7C · K2P2.1 (TREK-1), 1 mM K+ · the same entry in another collection · chain A against A, TM-score 1.00
P97438 · AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 2 (P97438) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P97438
Elsewhere: RCSB PDB 6W7C · PDBe 6W7C · UniProt P97438

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