Research workbench
Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation
Analyse Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6W6F
- Type
- protein
- Length
- 556 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable dimethyladenosine transferase
- EC
- 2.1.1.183
- UniProt
- Q9UNQ2
- Pockets
- 6 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Probable dimethyladenosine transferase (EC 2.1.1.183) | protein | 278 | 44% helix, 18% strand | Q9UNQ2 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 288 | 0.58 | 0.77 | 26 | empty |
| 2 | 70 | 0.53 | 0.86 | 15 | empty |
| 3 | 66 | 0.48 | 0.84 | 15 | empty |
| 4 | 126 | 0.39 | 0.74 | 16 | empty |
| 5 | 58 | 0.38 | 0.79 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1178 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6W6F · Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in ribosome… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UNQ2 · AlphaFold monomer V2.0 prediction for probable dimethyladenosine transferase (Q9UNQ2) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UNQ2
- Elsewhere: RCSB PDB 6W6F · PDBe 6W6F · UniProt Q9UNQ2
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