Research workbench
Camkii alpha-30 cryo-EM reconstruction - class B
Analyse Camkii alpha-30 cryo-EM reconstruction - class B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6W4P
- Type
- protein
- Length
- 1,789 residues
- Chains
- 13
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha
- EC
- 2.7.11.17
- UniProt
- Q9UQM7
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 6 distinct chains · 32% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, G | CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha (EC 2.7.11.17) | protein | 128 | 30% helix, 46% strand | Q9UQM7 |
| B, I | CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha (EC 2.7.11.17) | protein | 126 | 29% helix, 48% strand | Q9UQM7 |
| C, J | CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha (EC 2.7.11.17) | protein | 126 | 27% helix, 46% strand | Q9UQM7 |
| D, E, K, L | CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha (EC 2.7.11.17) | protein | 123 | 28% helix, 48% strand | Q9UQM7 |
| F, M | CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha (EC 2.7.11.17) | protein | 122 | 25% helix, 49% strand | Q9UQM7 |
| H | CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha (EC 2.7.11.17) | protein | 293 | 41% helix, 18% strand | Q9UQM7 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1053 | 0.84 | 0.85 | 116 | empty |
| 2 | 436 | 0.69 | 0.81 | 39 | empty |
| 3 | 403 | 0.68 | 0.80 | 34 | empty |
| 4 | 394 | 0.67 | 0.80 | 35 | empty |
| 5 | 409 | 0.67 | 0.79 | 31 | empty |
Interfaces
32 interfaces between chains.
- C–J · 1147 Ų buried · 9 hydrogen bonds · protein-protein
- F–L · 1136 Ų buried · 8 hydrogen bonds · protein-protein
- E–M · 1131 Ų buried · 9 hydrogen bonds · protein-protein
- A–G · 1131 Ų buried · 9 hydrogen bonds · protein-protein
- D–I · 1093 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- Q9UQM7 · AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type II… · a predicted model of the same protein · chain H against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UQM7
- Elsewhere: RCSB PDB 6W4P · PDBe 6W4P · UniProt Q9UQM7
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