Research workbench
Glycogen synthase kinase 3 beta complexed with axin peptide
Analyse Glycogen synthase kinase 3 beta complexed with axin peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1O9U
- Type
- protein
- Length
- 368 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycogen synthase kinase-3 beta; Axin peptide
- EC
- 2.7.1.37
- UniProt
- P49841, O15169
- Ligands
- ADZ
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycogen synthase kinase-3 beta (EC 2.7.1.37) | protein | 350 | 36% helix, 19% strand | P49841 |
| B | Axin peptide | protein | 18 | 89% helix, 0% strand | O15169 |
Ligands and binding sites
- ADZ · 9-methyl-9H-purin-6-amine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 253 | 0.62 | 0.80 | 26 | ADZ |
| 2 | 95 | 0.37 | 0.75 | 23 | empty |
| 3 | 58 | 0.25 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 726 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49841
- Every structure of UniProt O15169
- Elsewhere: RCSB PDB 1O9U · PDBe 1O9U · UniProt P49841 · UniProt O15169
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