Research workbench
Crystal structure of ligand-binding domain of campylobacter jejuni chemoreceptor TLP3 in complex with L-leucine
Analyse Crystal structure of ligand-binding domain of campylobacter jejuni… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6W3S
- Type
- protein
- Length
- 499 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methyl-accepting chemotaxis protein
- UniProt
- A0A3X8N4T9
- Ligands
- LEU, SO4
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methyl-accepting chemotaxis protein | protein | 247 | 42% helix, 28% strand | A0A3X8N4T9 |
| B | Methyl-accepting chemotaxis protein | protein | 252 | 42% helix, 28% strand | A0A3X8N4T9 |
Ligands and binding sites
- LEU · Leucine · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 812 | 0.74 | 0.79 | 55 | empty |
| 2 | 60 | 0.63 | 0.92 | 13 | LEU |
| 3 | 67 | 0.52 | 0.85 | 18 | LEU |
| 4 | 169 | 0.51 | 0.78 | 24 | empty |
| 5 | 135 | 0.40 | 0.74 | 31 | SO4 |
Interfaces
1 interface between chains.
- A–B · 971 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6W3S · Crystal structure of ligand-binding domain of Campylobacter jejuni chemoreceptor Tlp3 in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3X8N4T9
- Elsewhere: RCSB PDB 6W3S · PDBe 6W3S · UniProt A0A3X8N4T9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.