Research workbench
Crystal structure of the FAM46C/PLK4 complex
Analyse Crystal structure of the FAM46C/PLK4 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6W38
- Type
- protein
- Length
- 549 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Terminal nucleotidyltransferase 5C; SERINE/THREONINE-protein kinase PLK4
- EC
- 2.7.7.19, 2.7.11.21
- UniProt
- Q5VWP2, O00444
- Pockets
- 4 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Terminal nucleotidyltransferase 5C (EC 2.7.7.19) | protein | 331 | 49% helix, 18% strand | Q5VWP2 |
| B | SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21) | protein | 218 | 27% helix, 32% strand | O00444 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1079 | 0.81 | 0.82 | 77 | empty |
| 2 | 82 | 0.47 | 0.82 | 14 | empty |
| 3 | 115 | 0.44 | 0.78 | 20 | empty |
| 4 | 93 | 0.33 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 667 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6W38 · Crystal structure of the FAM46C/Plk4 complex · the same entry in another collection · chain A against A, TM-score 1.00
- O00444 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O00444) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q5VWP2 · AlphaFold monomer V2.0 prediction for terminal nucleotidyltransferase 5C (Q5VWP2) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5VWP2
- Every structure of UniProt O00444
- Elsewhere: RCSB PDB 6W38 · PDBe 6W38 · UniProt Q5VWP2 · UniProt O00444
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