Engineered TTLL6 mutant bound to alpha-elongation analog

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• ADP · Adenosine-5'-diphosphate · ligand · 4 copies · chains A, B, C, D
• RZP · (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid · ligand · 3 copies · chains B, D, A, C
• RZY · (2~{S})-2-[[[(1~{S})-1-acetamidoethyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid · ligand · chains A
• MG · Magnesium ion · metal · 8 copies · chains A, B, C, D
• GOL · Glycerol · additive · 18 copies · chains B, D, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6VZQ · Engineered TTLL6 mutant bound to alpha-elongation analog · the same entry in another collection · chain D against D, TM-score 1.00
• A4Q9E8 · AlphaFold monomer V2.0 prediction for tubulin polyglutamylase TTLL6 (A4Q9E8) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt A4Q9E8
• Elsewhere: RCSB PDB 6VZQ · PDBe 6VZQ · UniProt A4Q9E8