UniProt A4Q9E8
Tubulin polyglutamylase TTLL6 (A4Q9E8)
Tubulin polyglutamylase TTLL6 (UniProt A4Q9E8), EC 6.-.-.-, 6.3.2.-: 16 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 53 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- A4Q9E8
- Protein
- Tubulin polyglutamylase TTLL6
- EC
- 6.-.-.-, 6.3.2.-
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 53 · 5 records with a druggable one
Structures
17 records of A4Q9E8 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6VZQ | Engineered TTLL6 mutant bound to alpha-elongation analog | x-ray diffraction | A, B, C, D | ADP, RZY, MG, RZP | 15 (best 0.85) |
| 6VZQ | Engineered TTLL6 mutant bound to alpha-elongation analog | x-ray diffraction | A, B, C, D | ADP, RZY, MG, RZP | — |
| 6VZR | Engineered TTLL6 bound to the initiation analog | x-ray diffraction | A, B, C, D | 2TI, ADP, MG | — |
| 6VZR | Engineered TTLL6 bound to the initiation analog | x-ray diffraction | A, B, C, D | 2TI, ADP, MG | — |
| 6VZS | Engineered TTLL6 mutant bound to gamma-elongation analog | x-ray diffraction | A, B, C, D | ADP, S3A, MG | — |
| 6VZS | Engineered TTLL6 mutant bound to gamma-elongation analog | x-ray diffraction | A, B, C, D | ADP, S3A, MG | — |
| 6VZT | TTLL6 bound to ATP | x-ray diffraction | A, B | ATP, SO4, MG | — |
| 6VZT | TTLL6 bound to ATP | x-ray diffraction | A, B | ATP, SO4, MG | — |
| 6VZU | TTLL6 bound to alpha-elongation analog | x-ray diffraction | A, B, C, D | RZP, ADP, MG, CL, RZV | — |
| 6VZU | TTLL6 bound to alpha-elongation analog | x-ray diffraction | A, B, C, D | RZP, ADP, MG, CL, RZV | — |
| 6VZV | TTLL6 bound to gamma-elongation analog | x-ray diffraction | A, B, C, D | S3A, ADP, MG, S37 | — |
| 6VZV | TTLL6 bound to gamma-elongation analog | x-ray diffraction | A, B, C, D | S3A, ADP, MG, S37 | — |
| 6VZW | TTLL6 bound to the initiation analog | x-ray diffraction | A, B, C, D | 2TI, ADP, MG | 20 (best 0.84) |
| 6VZW | TTLL6 bound to the initiation analog | x-ray diffraction | A, B, C, D | 2TI, ADP, MG | — |
| 8T42 | Model of TTLL6 MTBH1-2 bound to microtubule | electron microscopy | N | — | 2 (best 0.75) |
| 8U3Z | Model of TTLL6 bound to microtubule from composite map | electron microscopy | N | ATP, MG | 11 (best 0.86) |
| A4Q9E8 | AlphaFold monomer V2.0 prediction for tubulin polyglutamylase TTLL6 (A4Q9E8) | predicted | A | — | 5 (best 0.82) |
Ligands
- MG · Magnesium ion · in 15 records
- ADP · Adenosine-5'-diphosphate · in 12 records
- 2TI · (2~{S})-2-[[[(3~{R})-3-acetamido-4-(ethylamino)-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid · in 4 records
- RZP · (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid · in 4 records
- S3A · (2~{S})-2-[[[(3~{R})-3-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid · in 4 records
- ATP · Adenosine-5'-triphosphate · in 3 records
- CL · Chloride ion · in 2 records
- RZV · (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-oxidanyl-phosphoryl]methyl]pentanedioic acid · in 2 records
- RZY · (2~{S})-2-[[[(1~{S})-1-acetamidoethyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid · in 2 records
- S37 · (2~{S})-2-[[[(3~{S})-3-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-oxidanyl-phosphoryl]methyl]pentanedioic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 6VZU chain A against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.41 Å
- 6VZU chain A against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.41 Å
- 6VZW chain A against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.45 Å
- 6VZW chain A against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.45 Å
- 6VZV chain D against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.45 Å
- 6VZV chain D against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.45 Å
- 6VZV chain A against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.48 Å
- 6VZV chain A against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.48 Å
- 6VZW chain D against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.50 Å
- 6VZW chain D against the predicted model A4Q9E8: TM-score 1.00, RMSD 0.50 Å
Elsewhere
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