Research workbench
Leg region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Analyse Leg region of the open conformation of the human type 1 insulin-like growth… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VWH
- Type
- protein
- Length
- 539 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
- EC
- 2.7.10.1
- UniProt
- P08069, P03069
- Pockets
- 4 · best druggability 0.75
Structure
electron microscopy · 2 distinct chains · 9% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (EC 2.7.10.1) | protein | 136 | 12% helix, 38% strand | P08069, P03069 |
| B | Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (EC 2.7.10.1) | protein | 403 | 7% helix, 34% strand | P08069, P03069 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.75 | 0.96 | 27 | empty |
| 2 | 118 | 0.47 | 0.79 | 24 | empty |
| 3 | 65 | 0.40 | 0.79 | 19 | empty |
| 4 | 66 | 0.29 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 610 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 6VWH · Leg region of the open conformation of the human type 1 insulin-like growth factor… · the same entry in another collection · chain A against A, TM-score 1.00
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain A against A, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08069
- Every structure of UniProt P03069
- Elsewhere: RCSB PDB 6VWH · PDBe 6VWH · UniProt P08069 · UniProt P03069
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