Crystal structure of human galectin-7 in complex with 4-O-beta-D- galactopyranosyl-D-glucose

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 54% strand (DSSP).

Ligands and binding sites

• LBL · (2~{R},3~{R},4~{R},5~{R})-4-[(2~{S},3~{R},4~{S},5~{R}, 6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-2,3,5, 6-tetrakis(oxidanyl)hexanal · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 831 Ų buried · 18 hydrogen bonds · protein-protein

Compared structures

• 6VTO · Crystal structure of human Galectin-7 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• P47929 · AlphaFold monomer V2.0 prediction for galectin-7 (P47929) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P47929
• Elsewhere: RCSB PDB 6VTO · PDBe 6VTO · UniProt P47929