Research workbench
The structure of the PP2A B56 subunit AIM1 complex
Analyse The structure of the PP2A B56 subunit AIM1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VRO
- Type
- protein
- Length
- 333 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform…
- UniProt
- Q13362, Q9Y4K1
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform | protein | 319 | 71% helix, 0% strand | Q13362 |
| B | BETA/GAMMA crystallin domain-containing protein 1 | protein | 14 | 0% helix, 0% strand | Q9Y4K1 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.44 | 0.82 | 15 | empty |
| 2 | 65 | 0.32 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 810 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6VRO · The structure of the PP2A B56 subunit AIM1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q13362 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 56 kda… · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9Y4K1 · AlphaFold monomer V2.0 prediction for BETA/GAMMA crystallin domain- containing protein 1… · a predicted model of the same protein · chain B against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13362
- Every structure of UniProt Q9Y4K1
- Elsewhere: RCSB PDB 6VRO · PDBe 6VRO · UniProt Q13362 · UniProt Q9Y4K1
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