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Nanodisc of full-length HIV-1 envelope glycoprotein clone AMC011 in complex with one PGT151 Fab and three 10E8 fabs

Analyse Nanodisc of full-length HIV-1 envelope glycoprotein clone AMC011 in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6VPX
Type
protein
Length
2,684 residues
Chains
17
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Ligands
44E, NAG, MAN, BMA, FUC, GAL

Structure

electron microscopy · 11 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein430——
E—protein419——
C—protein438——
D—protein129——
B—protein143——
F—protein120——
H, K, M—protein129——
L, N, O—protein108——
G, I, J—protein17——
P—protein134——
Q—protein109——

Ligands and binding sites

  • 44E · (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate · ligand · 3 copies · chains H, L, K, N, M, O
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 90 copies · chains A, E, C, D, B, P, Q, F, M
  • MAN · alpha-D-mannopyranose · sugar · 7 copies · chains C, P
  • BMA · beta-D-mannopyranose · sugar · 6 copies · chains P
  • FUC · alpha-L-fucopyranose · sugar · 6 copies · chains C, D, Q, B, P
  • GAL · beta-D-galactopyranose · sugar · 2 copies · chains Q, P

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6VPX · Nanodisc of full-length HIV-1 Envelope glycoprotein clone AMC011 in complex with one… · the same entry in another collection · chain A against A, TM-score 1.00

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