TPX2 residues 7-20 fused to aurora a residues 116-389 with C290 disulfide bonded to compound 8-34, and in complex with AMP-pnp

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• AMP · Adenosine monophosphate · ligand · 2 copies · chains A, B
• R74 · N~2~-[(2H-1,3-benzodioxol-5-yl)acetyl]-N-[(pyridin-4-yl)methyl]-L-cysteinamide · ligand · 2 copies · chains A, B
• MG · Magnesium ion · metal · 2 copies · chains A, B
• MLA · Malonic acid · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6VPM · TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to… · the same entry in another collection · chain A against A, TM-score 1.00
• O14965 · AlphaFold monomer V2.0 prediction for aurora kinase a (O14965) · a predicted model of the same protein · chain A against A, TM-score 0.87
• Q9ULW0 · AlphaFold monomer V2.0 prediction for targeting protein for XKLP2 (Q9ULW0) · a predicted model of the same protein · chain A against A, TM-score 0.14

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9ULW0
• Every structure of UniProt O14965
• Elsewhere: RCSB PDB 6VPM · PDBe 6VPM · UniProt Q9ULW0 · UniProt O14965