UniProt Q9ULW0
Targeting protein for XKLP2 (Q9ULW0)
Targeting protein for XKLP2 (UniProt Q9ULW0), EC 2.7.11.1: 18 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9ULW0
- Protein
- Targeting protein for XKLP2
- EC
- 2.7.11.1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 2 · 1 record with a druggable one
Structures
19 records of Q9ULW0 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OL5 | Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43 | x-ray diffraction | B | — | — |
| 1OL5 | Structure of aurora-a 122-403, phosphorylated on THR287, THR288 and bound to TPX2 1-43 | x-ray diffraction | B | — | — |
| 3E5A | Crystal structure of Aurora A in complex with VX-680 and TPX2 | x-ray diffraction | B | — | — |
| 3E5A | Crystal structure of aurora a in complex with vx-680 and TPX2 | x-ray diffraction | B | — | — |
| 3HA6 | Crystal structure of aurora A in complex with TPX2 and compound 10 | x-ray diffraction | B | — | — |
| 3HA6 | Crystal structure of aurora a in complex with TPX2 and compound 10 | x-ray diffraction | B | — | — |
| 4C3P | Structure of dephosphorylated Aurora A (122-403) bound to TPX2 and AMPPCP | x-ray diffraction | B, E | — | — |
| 4C3P | Structure of dephosphorylated aurora a (122-403) bound to TPX2 and amppcp | x-ray diffraction | B, E | — | — |
| 5LXM | Crystal structure of aurora-a bound to a hydrocarbon-stapled proteomimetic of TPX2 | x-ray diffraction | D | NH3 | — |
| 6BJC | TPX2_MINI decorated gmpcpp-microtubule | electron microscopy | T, P | — | — |
| 6VPG | TPX2 residues 7-20 fused to aurora a residues 116-389 in complex with AMP-pnp | x-ray diffraction | A | ANP, CL, MG | — |
| 6VPH | TPX2 residues 7-20 fused to aurora a residues 116-389 modified with cacodylate and in complex with… | x-ray diffraction | A | CL, ANP | — |
| 6VPI | TPX2 residues 7-20 fused to Aurora A residues 116-389 C247V + D256N + C319V triple mutant disulfide… | x-ray diffraction | A | ANP, MG | 2 (best 0.66) |
| 6VPI | TPX2 residues 7-20 fused to aurora a residues 116-389 C247V + D256N + C319V triple mutant disulfide… | x-ray diffraction | A | ANP, MG | — |
| 6VPJ | TPX2 residues 7-20 fused to aurora a residues 116-389 C247V + C319V double mutant dephosphorylated… | x-ray diffraction | A | GLC, ANP | — |
| 6VPL | TPX2 residues 7-20 fused to aurora a residues 116-389 with C290 disulfide bonded to compound 7-80… | x-ray diffraction | A, B | MG, ANP, R7D | — |
| 6VPM | TPX2 residues 7-20 fused to aurora a residues 116-389 with C290 disulfide bonded to compound 8-34… | x-ray diffraction | A, B | MG, AMP, R74 | — |
| 6XKA | TPX2 residues 7-20 fused to aurora a residues 116-389 dephosphorylated, and coalated on C290 | x-ray diffraction | A | — | — |
| Q9ULW0 | AlphaFold monomer V2.0 prediction for targeting protein for XKLP2 (Q9ULW0) | predicted | A | — | — |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 6 records
- MG · Magnesium ion · in 5 records
- CL · Chloride ion · in 2 records
- AMP · Adenosine monophosphate · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
- NH3 · Ammonia · in 1 record
- R74 · N~2~-[(2H-1,3-benzodioxol-5-yl)acetyl]-N-[(pyridin-4-yl)methyl]-L-cysteinamide · in 1 record
- R7D · N~2~-{(2R)-2-hydroxy-2-[4-(trifluoromethyl) phenyl]acetyl}-N-[(pyridin-2-yl)methyl]-L-cysteinamide · in 1 record
Experiment against prediction
- 6XKA chain A against the predicted model O14965: TM-score 0.93, RMSD 1.00 Å
- 6VPG chain A against the predicted model O14965: TM-score 0.93, RMSD 0.89 Å
- 6VPI chain A against the predicted model O14965: TM-score 0.89, RMSD 1.51 Å
- 6VPI chain A against the predicted model O14965: TM-score 0.89, RMSD 1.51 Å
- 6VPM chain A against the predicted model O14965: TM-score 0.87, RMSD 1.56 Å
- 6VPL chain A against the predicted model O14965: TM-score 0.87, RMSD 1.52 Å
- 6VPL chain B against the predicted model O14965: TM-score 0.86, RMSD 1.72 Å
- 6VPM chain B against the predicted model O14965: TM-score 0.86, RMSD 1.72 Å
- 6VPJ chain A against the predicted model O14965: TM-score 0.81, RMSD 2.65 Å
- 6VPH chain A against the predicted model O14965: TM-score 0.81, RMSD 2.33 Å
Elsewhere
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