Research workbench
TPX2 residues 7-20 fused to aurora a residues 116-389 in complex with AMP-pnp
Analyse TPX2 residues 7-20 fused to aurora a residues 116-389 in complex with AMP-pnp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VPG
- Type
- protein
- Length
- 282 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TPX2 fragment - aurora a kinase domain fusion
- EC
- 2.7.11.1
- UniProt
- Q9ULW0, O14965
- Ligands
- ANP, MG, CL
- Pockets
- 1 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TPX2 fragment - aurora a kinase domain fusion (EC 2.7.11.1) | protein | 282 | 39% helix, 18% strand | Q9ULW0, O14965 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
- CL · Chloride ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 336 | 0.69 | 0.82 | 37 | ANP, GOL, MG |
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 6VPG · TPX2 residues 7-20 fused to Aurora A residues 116-389 in complex with AMP-PNP · the same entry in another collection · chain A against A, TM-score 1.00
- O14965 · AlphaFold monomer V2.0 prediction for aurora kinase a (O14965) · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q9ULW0 · AlphaFold monomer V2.0 prediction for targeting protein for XKLP2 (Q9ULW0) · a predicted model of the same protein · chain A against A, TM-score 0.13
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ULW0
- Every structure of UniProt O14965
- Elsewhere: RCSB PDB 6VPG · PDBe 6VPG · UniProt Q9ULW0 · UniProt O14965
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