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NMR solution structure of GRB2-SH2 domain at pH 7

Analyse NMR solution structure of GRB2-SH2 domain at pH 7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6VK2
Type: protein
Length: 96 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Growth factor receptor-bound protein 2
UniProt: P62993
Pockets: 1 · best druggability 0.31

Structure

solution nmr · 1 distinct chain · 22% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Growth factor receptor-bound protein 2	protein	96	22% helix, 26% strand	P62993

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.31	0.76	9	empty

Compared structures

6VK2 · NMR solution structure of Grb2-SH2 domain at pH 7 · the same entry in another collection · chain A against A, TM-score 1.00
P62993 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 2 (P62993) · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62993
Elsewhere: RCSB PDB 6VK2 · PDBe 6VK2 · UniProt P62993

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