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Singlet tau fibril from corticobasal degeneration human brain tissue

Analyse Singlet tau fibril from corticobasal degeneration human brain tissue in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6VHA
Type: protein
Length: 321 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated protein tau
UniProt: P10636
Pockets: 5 · best druggability 0.52

Structure

electron microscopy · 1 distinct chain · 0% helix, 75% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E, F, G	Microtubule-associated protein tau	protein	107	0% helix, 75% strand	P10636

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	224	0.52	0.77	31	empty
2	62	0.47	0.84	20	empty
3	152	0.46	0.77	20	empty
4	87	0.45	0.80	18	empty
5	110	0.39	0.75	17	empty

Interfaces

3 interfaces between chains.

E–F · 4447 Å² buried · 165 hydrogen bonds · protein-protein
F–G · 4441 Å² buried · 162 hydrogen bonds · protein-protein
E–G · 27 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6VHA · Singlet Tau Fibril from Corticobasal Degeneration Human Brain Tissue · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10636
Elsewhere: RCSB PDB 6VHA · PDBe 6VHA · UniProt P10636

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