Research workbench
Crystal structure of human TEAD2 transcription factor in complex with flufenamic acid derivative
Analyse Crystal structure of human TEAD2 transcription factor in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VAH
- Type
- protein
- Length
- 403 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional enhancer factor tef-4
- UniProt
- Q15562
- Ligands
- QZ1, UNX
- Pockets
- 4 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 19% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional enhancer factor tef-4 | protein | 208 | 19% helix, 49% strand | Q15562 |
| B | Transcriptional enhancer factor tef-4 | protein | 195 | 18% helix, 51% strand | Q15562 |
Ligands and binding sites
- QZ1 · 2-fluoro-6-[(3-hexylphenyl)amino]benzoic acid · ligand · 2 copies · chains A, B
- UNX · Unknown atom or ion · ion · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 559 | 0.84 | 0.89 | 56 | QZ1 |
| 2 | 430 | 0.77 | 0.86 | 63 | QZ1 |
| 3 | 85 | 0.33 | 0.74 | 17 | empty |
| 4 | 62 | 0.33 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 589 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6VAH · Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid… · the same entry in another collection · chain A against A, TM-score 1.00
- Q15562 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-4 (Q15562) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15562
- Elsewhere: RCSB PDB 6VAH · PDBe 6VAH · UniProt Q15562
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