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Structure of TRPA1 bound with a-967079, pmal-C8

Analyse Structure of TRPA1 bound with a-967079, pmal-C8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6V9Y
Type: protein
Length: 2,248 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily a member 1
UniProt: O75762
Pockets: 20 · best druggability 0.81

Structure

electron microscopy · 1 distinct chain · 62% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D, C	Transient receptor potential cation channel subfamily a member 1	protein	562	62% helix, 2% strand	O75762

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	597	0.81	0.86	46	empty
2	729	0.70	0.77	87	empty
3	703	0.70	0.77	84	empty
4	133	0.67	0.88	23	empty
5	551	0.66	0.76	58	empty

Interfaces

6 interfaces between chains.

A–B · 3554 Å² buried · 14 hydrogen bonds · protein-protein
D–C · 3546 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 3526 Å² buried · 13 hydrogen bonds · protein-protein
A–D · 3507 Å² buried · 12 hydrogen bonds · protein-protein
B–D · 412 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6V9Y · Structure of TRPA1 bound with A-967079, PMAL-C8 · the same entry in another collection · chain A against A, TM-score 1.00
O75762 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75762
Elsewhere: RCSB PDB 6V9Y · PDBe 6V9Y · UniProt O75762

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