Research workbench
Crystal structure of monophosphorylated FGF receptor 2 isoform iiib with PTR657
Analyse Crystal structure of monophosphorylated FGF receptor 2 isoform iiib with PTR657 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6V6Q
- Type
- protein
- Length
- 1,132 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 2
- EC
- 2.7.10.1
- UniProt
- P21802
- Ligands
- ACP, MG
- Pockets
- 12 · best druggability 0.84
Structure
x-ray diffraction · 4 distinct chains · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 2 (EC 2.7.10.1) | protein | 286 | 41% helix, 17% strand | P21802 |
| B | Fibroblast growth factor receptor 2 (EC 2.7.10.1) | protein | 291 | 40% helix, 15% strand | P21802 |
| C | Fibroblast growth factor receptor 2 (EC 2.7.10.1) | protein | 279 | 39% helix, 18% strand | P21802 |
| D | Fibroblast growth factor receptor 2 (EC 2.7.10.1) | protein | 276 | 41% helix, 18% strand | P21802 |
Ligands and binding sites
- ACP · Phosphomethylphosphonic acid adenylate ester · ligand · 4 copies · chains A, B, C, D
- MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1135 | 0.84 | 0.85 | 99 | ACP, MG |
| 2 | 1177 | 0.82 | 0.83 | 87 | ACP, MG |
| 3 | 364 | 0.61 | 0.77 | 37 | empty |
| 4 | 202 | 0.47 | 0.75 | 21 | empty |
| 5 | 66 | 0.44 | 0.82 | 13 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1530 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 1346 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 743 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 80 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide, 2 modified (disulfide, phosphorylation).
Compared structures
- 6V6Q · Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657 · the same entry in another collection · chain D against D, TM-score 1.00
- P21802 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 2 (P21802) · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21802
- Elsewhere: RCSB PDB 6V6Q · PDBe 6V6Q · UniProt P21802
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.