Research workbench
Importin beta AA1-442 bound to five fxfg repeats from yeast NSP1P. second crystal form
Analyse Importin beta AA1-442 bound to five fxfg repeats from yeast NSP1P. second… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1O6O
- Type
- protein
- Length
- 1,333 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin beta-1 subunit; Nucleoporin NSP1
- UniProt
- Q14974, P14907
- Pockets
- 8 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Importin beta-1 subunit | protein | 439 | 75% helix, 0% strand | Q14974 |
| D, F | Nucleoporin NSP1 | protein | 5 | 0% helix, 0% strand | P14907 |
| E | Nucleoporin NSP1 | protein | 6 | 0% helix, 0% strand | P14907 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 604 | 0.65 | 0.75 | 42 | empty |
| 2 | 148 | 0.45 | 0.76 | 20 | empty |
| 3 | 114 | 0.42 | 0.76 | 21 | empty |
| 4 | 103 | 0.37 | 0.74 | 15 | empty |
| 5 | 73 | 0.34 | 0.75 | 15 | empty |
Interfaces
4 interfaces between chains.
- C–E · 370 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 350 Ų buried · 4 hydrogen bonds · protein-protein
- B–F · 343 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 237 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1O6O · Importin Beta aa1-442 bound to five FxFG repeats from yeast Nsp1p. Second crystal form · the same entry in another collection · chain F against F, TM-score 1.00
- Q14974 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q14974) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P14907 · AlphaFold monomer V2.0 prediction for nucleoporin NSP1 (P14907) · a predicted model of the same protein · chain D against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14974
- Every structure of UniProt P14907
- Elsewhere: RCSB PDB 1O6O · PDBe 1O6O · UniProt Q14974 · UniProt P14907
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