Research workbench
Crystal structure of an activated AKT/PROTEIN kinase B (pkb-pif chimera) ternary complex with AMP-pnp and GSK3 peptide
Analyse Crystal structure of an activated AKT/PROTEIN kinase B (pkb-pif chimera)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1O6L
- Type
- protein
- Length
- 327 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rac-beta SERINE/THREONINE protein kinase; Glycogen synthase kinase-3 beta
- EC
- 2.7.1.-, 2.7.1.37
- UniProt
- P31751, P49841
- Ligands
- ANP, MN
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rac-beta SERINE/THREONINE protein kinase (EC 2.7.1.-) | protein | 317 | 35% helix, 17% strand | P31751 |
| C | Glycogen synthase kinase-3 beta (EC 2.7.1.37) | protein | 10 | 0% helix, 20% strand | P49841 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A, C
- MN · Manganese (II) ion · metal · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 403 | 0.83 | 0.91 | 45 | ANP, MN |
| 2 | 54 | 0.39 | 0.81 | 12 | empty |
| 3 | 74 | 0.35 | 0.76 | 14 | empty |
| 4 | 72 | 0.33 | 0.76 | 18 | empty |
| 5 | 57 | 0.31 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–C · 743 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 1O6L · Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex… · the same entry in another collection · chain A against A, TM-score 1.00
- P31751 · AlphaFold monomer V2.0 prediction for rac-beta SERINE/THREONINE- protein kinase (P31751) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31751
- Every structure of UniProt P49841
- Elsewhere: RCSB PDB 1O6L · PDBe 1O6L · UniProt P31751 · UniProt P49841
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.