Research workbench

Unliganded elic in popc-only nanodiscs.

Analyse Unliganded elic in popc-only nanodiscs. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6V0B
Type: protein
Length: 1,530 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma-aminobutyric-acid receptor subunit beta-1
UniProt: E0SJQ4
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 21% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E	Gamma-aminobutyric-acid receptor subunit beta-1	protein	306	21% helix, 26% strand	E0SJQ4

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	737	0.83	0.87	61	empty
2	872	0.80	0.83	100	empty
3	357	0.78	0.87	51	empty
4	372	0.77	0.87	53	empty
5	655	0.76	0.82	75	empty

Interfaces

5 interfaces between chains.

C–D · 2581 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 2542 Å² buried · 10 hydrogen bonds · protein-protein
D–E · 2511 Å² buried · 9 hydrogen bonds · protein-protein
A–E · 2490 Å² buried · 9 hydrogen bonds · protein-protein
B–C · 2486 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

6V0B · Unliganded ELIC in POPC-only nanodiscs. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E0SJQ4
Elsewhere: RCSB PDB 6V0B · PDBe 6V0B · UniProt E0SJQ4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.