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Solution structure of KTI55-kringle 2 complex

Analyse Solution structure of KTI55-kringle 2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6UZ5
Type: protein
Length: 137 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasminogen; M protein
EC: 3.4.21.7
UniProt: P00747, M4I070
Pockets: 1 · best druggability 0.60

Structure

solution nmr · 2 distinct chains · 15% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plasminogen (EC 3.4.21.7)	protein	80	4% helix, 16% strand	P00747
B	M protein	protein	57	32% helix, 0% strand	M4I070

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	263	0.60	0.79	36	empty

Interfaces

1 interface between chains.

A–B · 608 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

6UZ5 · Solution structure of KTI55-Kringle 2 complex · the same entry in another collection · chain A against A, TM-score 1.00
P00747 · AlphaFold monomer V2.0 prediction for plasminogen (P00747) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00747
Every structure of UniProt M4I070
Elsewhere: RCSB PDB 6UZ5 · PDBe 6UZ5 · UniProt P00747 · UniProt M4I070

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