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Cryo-EM structure of nucleotide-free msba reconstituted into peptidiscs, conformation 1

Analyse Cryo-EM structure of nucleotide-free msba reconstituted into peptidiscs… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6UZ2
Type: protein
Length: 1,140 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipid a export ATP-BINDING/PERMEASE protein msba
EC: 7.5.2.6
UniProt: C3TGA2
Pockets: 18 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 66% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Lipid a export ATP-BINDING/PERMEASE protein msba (EC 7.5.2.6)	protein	570	66% helix, 7% strand	C3TGA2

Pockets

18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1035	0.84	0.84	85	empty
2	897	0.82	0.85	106	empty
3	880	0.82	0.84	98	empty
4	640	0.79	0.85	93	empty
5	351	0.75	0.86	66	empty

Interfaces

1 interface between chains.

A–B · 4598 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

6UZ2 · Cryo-EM structure of nucleotide-free MsbA reconstituted into peptidiscs, conformation 1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C3TGA2
Elsewhere: RCSB PDB 6UZ2 · PDBe 6UZ2 · UniProt C3TGA2

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