UniProt C3TGA2
Lipid A export ATP-binding/permease protein MsbA (C3TGA2)
Lipid A export ATP-binding/permease protein MsbA (UniProt C3TGA2), EC 3.6.3.-, 7.5.2.6: 6 experimental structures on GenesisL1, 3 ligands bound, 51 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- C3TGA2
- Protein
- Lipid A export ATP-binding/permease protein MsbA
- EC
- 3.6.3.-, 7.5.2.6
- Experimental structures
- 6
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 51 · 3 records with a druggable one
Structures
6 records of C3TGA2 in the MolNFT archive: 6 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6UZ2 | Cryo-EM structure of nucleotide-free MsbA reconstituted into peptidiscs, conformation 1 | electron microscopy | A, B | — | 18 (best 0.84) |
| 6UZ2 | Cryo-EM structure of nucleotide-free msba reconstituted into peptidiscs, conformation 1 | electron microscopy | A, B | — | — |
| 6UZL | Cryo-EM structure of nucleotide-free MsbA reconstituted into peptidiscs, conformation 2 | electron microscopy | A, B | — | 16 (best 0.85) |
| 6UZL | Cryo-EM structure of nucleotide-free msba reconstituted into peptidiscs, conformation 2 | electron microscopy | A, B | — | — |
| 7PH7 | Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position T68C | electron microscopy | A, B | EIW | — |
| 8DMM | Structure of the vanadate-trapped MsbA bound to KDL | electron microscopy | A, B | AOV, KDL | 17 (best 0.90) |
Ligands
- AOV · Adp orthovanadate · in 1 record
- EIW · (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl) ethyl]-4-[(2~{R},3~{S},4~{S},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{S},5~{S}, 6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,5-bis(oxidanyl)oxan-2-yl]oxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-4-[(3~{R})-3-nonanoyloxytetradecanoyl]oxy-5-[[(3~{R})-3-octanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S}, 4~{S},5~{S},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanylnonanoyl]amino]-4-[(3~{R})-3-oxidanylt · in 1 record
- KDL · (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl) ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R}, 5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S}, 4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(o · in 1 record
Elsewhere
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