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Ligand · EIW

EIW · (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl) ethyl]-4-[(2~{R},3~{S},4~{S},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{S},5~{S}, 6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,5-bis(oxidanyl)oxan-2-yl]oxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-4-[(3~{R})-3-nonanoyloxytetradecanoyl]oxy-5-[[(3~{R})-3-octanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S}, 4~{S},5~{S},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanylnonanoyl]amino]-4-[(3~{R})-3-oxidanylt

EIW, (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl) ethyl]-4-[(2~{R},3~{S},4~{S},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{S},5~{S}…

Component
EIW
Formula
C102 H186 N2 O44 P2
Class
ligand
Structures
3
PDB entries
2

Binding sites

EIW in 3 structures; the first of them:

  • 7PH2 · Nanodisc reconstituted MsbA in complex with nanobodies, spin-labeled at position A60C · EIW A601 · binds ASP41, MET44, LEU45, LEU48, LEU51, MET75, ARG78, LEU171 and 33 more
  • 7PH2 · Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position A60C · EIW A601 · binds ASP41, LEU45, LEU48, LEU51, LEU171, VAL178, GLN256, ALA259 and 22 more
  • 7PH7 · Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position T68C · EIW A601 · binds ASP41, LEU48, ARG78, LEU171, GLN256, ALA259, THR285, PHE288 and 20 more

Residues it binds most

LEU 3, MET 3, ALA 3, ARG 3, ASP 3, SER 3, ILE 3, PHE 3, GLN 3, THR 2 (residue and the binding sites it lines).

Found with

  • 88T · (1~{R},4~{R},11~{S},14~{S},19~{Z})-19-[2-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]ethylimino]-7,8,17, 18-tetraoxa-1,4,11,14-tetrazatricyclo[12.6.2.2^{4, 11}]tetracosane-6,9,16-trione
  • GD · Gadolinium atom

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