Research workbench
Structure of calcineurin bound to RCAN1
Analyse Structure of calcineurin bound to RCAN1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UUQ
- Type
- protein
- Length
- 320 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 2B catalytic subunit alpha isoform; Calcipressin-1
- EC
- 3.1.3.16
- UniProt
- Q08209, P53805
- Ligands
- ZN, FE, PO4
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) | protein | 311 | 32% helix, 21% strand | Q08209 |
| B | Calcipressin-1 | protein | 9 | 0% helix, 56% strand | P53805 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
- FE · Fe (III) ion · metal · chains A
- PO4 · Phosphate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.46 | 0.77 | 31 | PO4, ZN |
Interfaces
1 interface between chains.
- A–B · 553 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6UUQ · Structure of Calcineurin bound to RCAN1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q08209 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2B catalytic… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P53805 · AlphaFold monomer V2.0 prediction for calcipressin-1 (P53805) · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08209
- Every structure of UniProt P53805
- Elsewhere: RCSB PDB 6UUQ · PDBe 6UUQ · UniProt Q08209 · UniProt P53805
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