UniProt Q08209
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (Q08209)
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (UniProt Q08209), EC 3.1.3.16: 30 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 7 pockets. Binding sites, druggability and…
- UniProt
- Q08209
- Protein
- Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
- EC
- 3.1.3.16
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 7 · 2 records with a druggable one
Structures
31 records of Q08209 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AUI | Human calcineurin heterodimer | x-ray diffraction | A | — | — |
| 1AUI | Human calcineurin heterodimer | x-ray diffraction | A | — | — |
| 1M63 | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of… | x-ray diffraction | A, E | — | — |
| 1M63 | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of… | x-ray diffraction | A, E | — | — |
| 1MF8 | Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin | x-ray diffraction | A | — | — |
| 1MF8 | Crystal structure of human calcineurin complexed with cyclosporin a and human cyclophilin | x-ray diffraction | A | — | — |
| 2JOG | Structure of the calcineurin-NFAT complex | solution nmr | A | — | — |
| 2JOG | Structure of the calcineurin-nfat complex | solution nmr | A | — | — |
| 2JZI | Structure of Calmodulin complexed with the Calmodulin Binding Domain of Calcineurin | solution nmr | B | — | — |
| 2JZI | Structure of calmodulin complexed with the calmodulin binding domain of calcineurin | solution nmr | B | — | — |
| 2P6B | Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide | x-ray diffraction | A, C | — | — |
| 2P6B | Crystal structure of human calcineurin in complex with pvivit peptide | x-ray diffraction | A, C | — | — |
| 2R28 | The complex Structure of Calmodulin Bound to a Calcineurin Peptide | x-ray diffraction | C, D | — | — |
| 2R28 | The complex structure of calmodulin bound to a calcineurin peptide | x-ray diffraction | C, D | — | — |
| 2W73 | High-resolution structure of the complex between calmodulin and a peptide from calcineurin A | x-ray diffraction | K, L, M, O | — | — |
| 2W73 | High-resolution structure of the complex between calmodulin and a peptide from calcineurin a | x-ray diffraction | K, L, M, O | — | — |
| 3LL8 | Crystal Structure of Calcineurin in Complex with AKAP79 Peptide | x-ray diffraction | A, C | — | — |
| 3LL8 | Crystal structure of calcineurin in complex with AKAP79 peptide | x-ray diffraction | A, C | — | — |
| 4F0Z | Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African… | x-ray diffraction | A | — | — |
| 4F0Z | Crystal structure of calcineurin in complex with the calcineurin- inhibiting domain of the african… | x-ray diffraction | A | — | — |
| 4Q5U | Structure of calmodulin bound to its recognition site from calcineurin | x-ray diffraction | C | — | — |
| 4Q5U | Structure of calmodulin bound to its recognition site from calcineurin | x-ray diffraction | C | — | — |
| 5C1V | Crystal structure analysis of catalytic subunit of human calcineurin | x-ray diffraction | A, B | — | — |
| 5SVE | Structure of Calcineurin in complex with NFATc1 LxVP peptide | x-ray diffraction | A | FE, ZN | 3 (best 0.62) |
| 5SVE | Structure of calcineurin in complex with NFATC1 lxvp peptide | x-ray diffraction | A | FE, ZN | — |
| 6NUC | Structure of calcineurin in complex with NHE1 peptide | x-ray diffraction | A | FE, ZN, PO4, NA | — |
| 6NUF | Structure of calcineurin in complex with NHE1 peptide | x-ray diffraction | A | FE, ZN, PO4, NA | — |
| 6NUU | Structure of calcineurin mutant in complex with NHE1 peptide | x-ray diffraction | A | FE, ZN, PO4 | — |
| 6UUQ | Structure of Calcineurin bound to RCAN1 | x-ray diffraction | A | PO4, ZN, FE | 1 (best 0.46) |
| 6UUQ | Structure of calcineurin bound to RCAN1 | x-ray diffraction | A | PO4, ZN, FE | — |
| Q08209 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2B catalytic subunit… | predicted | A | — | 3 (best 0.72) |
Ligands
Experiment against prediction
- 5C1V chain A against the predicted model Q08209: TM-score 0.99, RMSD 0.58 Å
- 2JOG chain A against the predicted model Q08209: TM-score 0.99, RMSD 0.83 Å
- 2JOG chain A against the predicted model Q08209: TM-score 0.99, RMSD 0.83 Å
- 6UUQ chain A against the predicted model Q08209: TM-score 0.98, RMSD 1.09 Å
- 6UUQ chain A against the predicted model Q08209: TM-score 0.98, RMSD 1.09 Å
- 6NUF chain A against the predicted model Q08209: TM-score 0.98, RMSD 1.35 Å
- 6NUC chain A against the predicted model Q08209: TM-score 0.98, RMSD 1.37 Å
- 2P6B chain A against the predicted model Q08209: TM-score 0.98, RMSD 1.43 Å
- 2P6B chain A against the predicted model Q08209: TM-score 0.98, RMSD 1.43 Å
- 3LL8 chain A against the predicted model Q08209: TM-score 0.98, RMSD 1.41 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.