Research workbench
Telomerase reverse transcriptase binary complex with Y256A mutation, TERT:DNA
Analyse Telomerase reverse transcriptase binary complex with Y256A mutation, TERT:DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6USQ
- Type
- protein + DNA + RNA
- Length
- 627 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase reverse transcriptase; DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)…
- EC
- 2.7.7.49
- UniProt
- Q0QHL8
- Ligands
- MG
- Pockets
- 7 · best druggability 0.84
Structure
x-ray diffraction · 3 distinct chains · 49% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 596 | 49% helix, 13% strand | Q0QHL8 |
| E | DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)- 3') | dna | 15 | — | — |
| F | DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)- R(P*GP*AP*C)-D(P*C)-3') | rna | 16 | — | — |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1001 | 0.84 | 0.85 | 112 | empty |
| 2 | 260 | 0.65 | 0.82 | 37 | empty |
| 3 | 175 | 0.62 | 0.84 | 22 | empty |
| 4 | 120 | 0.48 | 0.79 | 20 | empty |
| 5 | 66 | 0.35 | 0.77 | 12 | empty |
Interfaces
3 interfaces between chains.
- E–F · 678 Ų buried · 43 hydrogen bonds · nucleic-nucleic
- A–E · 585 Ų buried · 11 hydrogen bonds · protein-nucleic
- A–F · 390 Ų buried · 2 hydrogen bonds · protein-nucleic
Compared structures
- 6USQ · Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0QHL8
- Elsewhere: RCSB PDB 6USQ · PDBe 6USQ · UniProt Q0QHL8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.