Research workbench
Telomerase reverse transcriptase product complex, TERT:DNA
Analyse Telomerase reverse transcriptase product complex, TERT:DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6USP
- Type
- protein + DNA + RNA
- Length
- 628 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase reverse transcriptase; DNA (5'- D(P*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A…
- EC
- 2.7.7.49
- UniProt
- Q0QHL8
- Ligands
- MG
- Pockets
- 11 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 596 | 48% helix, 13% strand | Q0QHL8 |
| E | DNA (5'- D(P*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*G)-3') | dna | 16 | — | — |
| F | DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)- R(P*GP*AP*C)-D(P*C)-3') | rna | 16 | — | — |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1154 | 0.76 | 0.79 | 77 | empty |
| 2 | 918 | 0.76 | 0.79 | 66 | empty |
| 3 | 72 | 0.70 | 0.95 | 22 | empty |
| 4 | 50 | 0.68 | 0.96 | 21 | empty |
| 5 | 220 | 0.64 | 0.83 | 37 | empty |
Interfaces
3 interfaces between chains.
- A–E · 866 Ų buried · 22 hydrogen bonds · protein-nucleic
- E–F · 734 Ų buried · 58 hydrogen bonds · nucleic-nucleic
- A–F · 471 Ų buried · 0 hydrogen bonds · protein-nucleic
Compared structures
- 6USP · Telomerase Reverse Transcriptase product complex, TERT:DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0QHL8
- Elsewhere: RCSB PDB 6USP · PDBe 6USP · UniProt Q0QHL8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.