Research workbench
Complex structure of human poly-ADP-ribosyltransferase TNKS1 ARC2-ARC3 and P antigen family member 4 (PAGE4)
Analyse Complex structure of human poly-ADP-ribosyltransferase TNKS1 ARC2-ARC3 and P… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6URQ
- Type
- protein
- Length
- 632 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Poly [ADP-ribose] polymerase tankyrase-1; P antigen family member 4
- EC
- 2.4.2.30, 2.4.2.-
- UniProt
- O95271, O60829
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 52% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30, 2.4.2.-) | protein | 309 | 53% helix, 0% strand | O95271 |
| B | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30, 2.4.2.-) | protein | 307 | 52% helix, 0% strand | O95271 |
| C, D | P antigen family member 4 | protein | 8 | 0% helix, 0% strand | O60829 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 532 | 0.66 | 0.77 | 43 | empty |
| 2 | 59 | 0.26 | 0.72 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2064 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 592 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 589 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6URQ · Complex structure of human poly-ADP-ribosyltransferase TNKS1 ARC2-ARC3 and P antigen… · the same entry in another collection · chain A against A, TM-score 1.00
- O60829 · AlphaFold monomer V2.0 prediction for P antigen family member 4 (O60829) · a predicted model of the same protein · chain C against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95271
- Every structure of UniProt O60829
- Elsewhere: RCSB PDB 6URQ · PDBe 6URQ · UniProt O95271 · UniProt O60829
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.