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BRD4-BD1 in complex with the cyclic peptide 4.2_1

Analyse BRD4-BD1 in complex with the cyclic peptide 4.2_1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ULV
Type: protein
Length: 461 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O60885
Ligands: ACE, IOD, NH2

Structure

x-ray diffraction · 5 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	108	—	O60885
B	—	protein	105	—	O60885
C	—	protein	109	—	O60885
D	—	protein	111	—	O60885
E, G	—	protein	14	—	—

Ligands and binding sites

ACE · Acetyl group · ligand · 2 copies · chains A, E, G
IOD · Iodide ion · ion · 7 copies · chains A, B, C, G, D, E
NH2 · Amino group · ion · 2 copies · chains A, E, B, G
GOL · Glycerol · additive · 2 copies · chains C, D, E, G
B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6ULV · BRD4-BD1 in complex with the cyclic peptide 4.2_1 · the same entry in another collection · chain G against G, TM-score 1.00
O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60885
Elsewhere: RCSB PDB 6ULV · PDBe 6ULV · UniProt O60885

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