Research workbench
Crystal structure of rhog and elmo complex
Analyse Crystal structure of rhog and elmo complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UKA
- Type
- protein
- Length
- 249 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho-related GTP-binding protein rhog; Engulfment and cell motility protein 2
- UniProt
- P84095, Q8BHL5
- Ligands
- GNP, MG
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho-related GTP-binding protein rhog | protein | 177 | 40% helix, 27% strand | P84095 |
| B | Engulfment and cell motility protein 2 | protein | 72 | 24% helix, 36% strand | Q8BHL5 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.56 | 0.82 | 28 | GNP, MG |
Interfaces
1 interface between chains.
- A–B · 505 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6UKA · Crystal structure of RHOG and ELMO complex · the same entry in another collection · chain A against A, TM-score 1.00
- P84095 · AlphaFold monomer V2.0 prediction for rho-related GTP-binding protein rhog (P84095) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q8BHL5 · AlphaFold monomer V2.0 prediction for engulfment and cell motility protein 2 (Q8BHL5) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84095
- Every structure of UniProt Q8BHL5
- Elsewhere: RCSB PDB 6UKA · PDBe 6UKA · UniProt P84095 · UniProt Q8BHL5
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