Research workbench
Hhat wild type peptide kqwlvwlll presented by HLA-A206
Analyse Hhat wild type peptide kqwlvwlll presented by HLA-A206 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UJQ
- Type
- protein
- Length
- 384 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MHC class I antigen; Beta-2-microglobulin; Protein-cysteine N-palmitoyltransferase hhat
- UniProt
- U5YJP1, P61769, Q5VTY9
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MHC class I antigen | protein | 275 | 26% helix, 40% strand | U5YJP1 |
| B | Beta-2-microglobulin | protein | 100 | 0% helix, 49% strand | P61769 |
| C | Protein-cysteine N-palmitoyltransferase hhat | protein | 9 | 0% helix, 0% strand | Q5VTY9 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 612 | 0.69 | 0.78 | 51 | empty |
| 2 | 177 | 0.48 | 0.76 | 31 | empty |
| 3 | 54 | 0.42 | 0.82 | 19 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1386 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 942 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6UJQ · HHAT Wild Type Peptide KQWLVWLLL Presented by HLA-A206 · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q5VTY9 · AlphaFold monomer V2.0 prediction for protein-cysteine N-palmitoyltransferase hhat… · a predicted model of the same protein · chain C against A, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt U5YJP1
- Every structure of UniProt P61769
- Every structure of UniProt Q5VTY9
- Elsewhere: RCSB PDB 6UJQ · PDBe 6UJQ · UniProt U5YJP1 · UniProt P61769 · UniProt Q5VTY9
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