Research workbench
Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution of 3.4 ångström
Analyse Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UGH
- Type
- protein
- Length
- 895 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein arginine N-methyltransferase 5; Methylosome protein 50
- EC
- 2.1.1.320
- UniProt
- O14744, Q9BQA1
- Pockets
- 5 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 21% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein arginine N-methyltransferase 5 (EC 2.1.1.320) | protein | 594 | 31% helix, 25% strand | O14744 |
| B | Methylosome protein 50 | protein | 301 | 1% helix, 48% strand | Q9BQA1 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1006 | 0.82 | 0.84 | 76 | empty |
| 2 | 653 | 0.79 | 0.84 | 67 | empty |
| 3 | 239 | 0.56 | 0.78 | 26 | empty |
| 4 | 241 | 0.52 | 0.75 | 23 | empty |
| 5 | 207 | 0.49 | 0.76 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 2148 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 6UGH · Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution of 3.4… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BQA1 · AlphaFold monomer V2.0 prediction for methylosome protein 50 (Q9BQA1) · a predicted model of the same protein · chain B against A, TM-score 0.99
- O14744 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 5 (O14744) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14744
- Every structure of UniProt Q9BQA1
- Elsewhere: RCSB PDB 6UGH · PDBe 6UGH · UniProt O14744 · UniProt Q9BQA1
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