Research workbench
Mthk closed state with edta
Analyse Mthk closed state with edta in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6U6D
- Type
- protein
- Length
- 2,156 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium-gated potassium channel mthk
- UniProt
- O27564
- Ligands
- K
- Pockets
- 18 · best druggability 0.79
Structure
electron microscopy · 2 distinct chains · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Calcium-gated potassium channel mthk | protein | 317 | 46% helix, 13% strand | O27564 |
| B, D, F, H | Calcium-gated potassium channel mthk | protein | 222 | 33% helix, 21% strand | O27564 |
Ligands and binding sites
- K · Potassium ion · metal · 2 copies · chains A, C, E, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1042 | 0.79 | 0.80 | 72 | empty |
| 2 | 484 | 0.72 | 0.82 | 37 | empty |
| 3 | 457 | 0.71 | 0.81 | 36 | empty |
| 4 | 507 | 0.71 | 0.81 | 49 | empty |
| 5 | 515 | 0.70 | 0.80 | 47 | empty |
Interfaces
18 interfaces between chains.
- A–B · 3807 Ų buried · 45 hydrogen bonds · protein-protein
- C–D · 3801 Ų buried · 41 hydrogen bonds · protein-protein
- G–H · 3783 Ų buried · 45 hydrogen bonds · protein-protein
- E–F · 3777 Ų buried · 45 hydrogen bonds · protein-protein
- A–G · 1441 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6U6D · MthK closed state with EDTA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O27564
- Elsewhere: RCSB PDB 6U6D · PDBe 6U6D · UniProt O27564
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