Research workbench
Structure of human ULK4 in complex with an inhibitor
Analyse Structure of human ULK4 in complex with an inhibitor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6U5L
- Type
- protein
- Length
- 276 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase ULK4
- EC
- 2.7.11.1
- UniProt
- Q96C45
- Ligands
- 3RJ
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase ULK4 (EC 2.7.11.1) | protein | 276 | 41% helix, 17% strand | Q96C45 |
Ligands and binding sites
- 3RJ · N~2~-(1H-benzimidazol-6-yl)-N~4~-(5-cyclobutyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine · ligand · chains A
- GOL · Glycerol · additive · 4 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 352 | 0.66 | 0.80 | 35 | 3RJ |
| 2 | 180 | 0.50 | 0.77 | 24 | empty |
Compared structures
- 6U5L · Structure of human ULK4 in complex with an inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- Q96C45 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase ULK4 (Q96C45) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96C45
- Elsewhere: RCSB PDB 6U5L · PDBe 6U5L · UniProt Q96C45
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